Thalamic input to accommodating (ACC) LA interneurons is significantly larger than cortical input to the same subtype¶

Claim · All claims
Evidence · 1 study · causal r2 · q3
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Among LA interneuron subtypes, AT-evoked EPSC amplitude in ACC cells significantly exceeded AC-evoked amplitude (p = 0.0137). → Polepalli 2020

Evidence¶

Polepalli 2020¶

Polepalli, J. S., Gooch, H. & Sah, P. (2020). Diversity of interneurons in the lateral and basal amygdala. npj Science of Learning 5:10. https://doi.org/10.1038/s41539-020-0071-z

q3 · i? · causal · r2

Subtype-wise comparison of light-evoked EPSC amplitudes in LA interneurons; "AT input to ACC neurons was significantly larger than AC input (p = 0.0137)". Only a p-value printed; no effect size.

"while the total numbers of some subtypes were small, AT input to ACC neurons was significantly larger than AC input ( p = 0.0137; Fig. 3e)"

Discussion¶

Related Claims¶

• Auditory thalamic and cortical input to BLA interneurons is concentrated in the LA: thalamic EPSCs are larger in LA than BA interneurons (191 vs 53 pA, p < 0.0001) — related
• Auditory input drives feed-forward inhibition onto LA interneurons, with cortical input producing a smaller E/I ratio than thalamic input — related
• Glutamatergic synapses on BA interneurons are less rectifying than those on LA interneurons, indicating fewer calcium-permeable GluR2-lacking AMPARs in the BA — related
• Long-term potentiation at cortical inputs is restricted to LA interneurons and cannot be induced in BA interneurons — related
• NMDAR subunit stoichiometry differs between LA and BA interneurons: LA NMDAR EPSCs decay faster and LA interneurons include a GluN2A-dominant majority plus NMDAR-lacking cells, absent in the BA