Long-term potentiation at cortical inputs is restricted to LA interneurons and cannot be induced in BA interneurons¶

Claim · All claims
Evidence · 1 study · causal r1 · q3
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Tetanic stimulation failed to evoke LTP at cortical input to BA interneurons (n = 8), while LA interneurons expressing GluN2A-containing NMDARs showed reliable potentiation (normalized EPSC amplitude = 1.5 ± 0.1; n = 9). → Polepalli 2020

Evidence¶

Polepalli 2020¶

Polepalli, J. S., Gooch, H. & Sah, P. (2020). Diversity of interneurons in the lateral and basal amygdala. npj Science of Learning 5:10. https://doi.org/10.1038/s41539-020-0071-z

q3 · i? · causal · r1

Slice LTP experiments using tetanic stimulation (100 Hz, 300 ms × 3); "tetanic stimulation of cortical input to interneurons in the BA failed to evoke LTP (n = 8)"; LA potentiation normalized EPSC amplitude = 1.5 ± 0.1 (n = 9), a raw normalized amplitude, not a standardised effect size.

"tetanic stimulation of cortical input to interneurons in the BA failed to evoke LTP ( n = 8; Fig. 6 a, b). In contrast, as reported previously 38, tetanic stimulation of cortical inputs onto LA interneurons expressing GluN2A-containing NMDA receptors reliably evoked LTP (normalized EPSC amplitude = 1.5 ± 0.1; n = 9"

Discussion¶

Related Claims¶

• Glutamatergic synapses on BA interneurons are less rectifying than those on LA interneurons, indicating fewer calcium-permeable GluR2-lacking AMPARs in the BA — related
• NMDAR subunit stoichiometry differs between LA and BA interneurons: LA NMDAR EPSCs decay faster and LA interneurons include a GluN2A-dominant majority plus NMDAR-lacking cells, absent in the BA — related
• Auditory thalamic and cortical input to BLA interneurons is concentrated in the LA: thalamic EPSCs are larger in LA than BA interneurons (191 vs 53 pA, p < 0.0001) — related
• Thalamic input to accommodating (ACC) LA interneurons is significantly larger than cortical input to the same subtype — related
• Auditory input drives feed-forward inhibition onto LA interneurons, with cortical input producing a smaller E/I ratio than thalamic input — related