Glutamatergic synapses on BA interneurons are less rectifying than those on LA interneurons, indicating fewer calcium-permeable GluR2-lacking AMPARs in the BA¶

Claim · All claims
Evidence · 1 study · causal r2 · q3
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? The AMPAR rectification index is significantly higher in BA (0.35 ± 0.04) than LA (0.25 ± 0.02) interneurons (p < 0.05). → Polepalli 2020

Evidence¶

Polepalli 2020¶

Polepalli, J. S., Gooch, H. & Sah, P. (2020). Diversity of interneurons in the lateral and basal amygdala. npj Science of Learning 5:10. https://doi.org/10.1038/s41539-020-0071-z

q3 · i? · causal · r2

Voltage-clamp recordings with cesium-based internal solution and GABAA blockade, evoked by internal/external capsule stimulation at −60 and +40 mV; "was significantly higher in BA interneurons (BA: 0.35 ± 0.04, n = 45; LA: 0.25 ± 0.02, n = 54". NMDA/AMPA ratio did not differ between nuclei (p > 0.05); no standardised effect size printed.

"and was significantly higher in BA interneurons (BA: 0.35 ± 0.04, n = 45; LA: 0.25 ± 0.02, n = 54; p < 0.05; Fig. 5a, c"

Discussion¶

Related Claims¶

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• NMDAR subunit stoichiometry differs between LA and BA interneurons: LA NMDAR EPSCs decay faster and LA interneurons include a GluN2A-dominant majority plus NMDAR-lacking cells, absent in the BA — related
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