CGRP silencing reduces freezing at high footshock intensities where control mice show significant increases in freezing¶

Claim · All claims
Evidence · 1 study (2 entries) · causal r1–r2 · q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? At 0.4 and 0.5 mA, control mice showed significant increases in freezing while TetTox mice maintained significantly lower freezing levels. → Hanny Hayeon Lee 2026 q3 i? Retention test 3 freezing percentage showed a significant CGRP manipulation × Footshock Intensity interaction. → Hanny Hayeon Lee 2026 (2)

Evidence¶

Hanny Hayeon Lee 2026¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i? · causal · r1

Freezing analysis in the CGRP-silencing experiment (TetTox vs eYFP controls, n = 7 per intensity cohort) during retention tests: at 0.4 and 0.5 mA "the TetTox mice maintained significantly lower freezing levels" than controls.

"However, at 0.4 and 0.5 mA, the control group exhibited significant increases in freezing, while the TetTox mice maintained significantly lower freezing levels (Fig. 4h)."

Hanny Hayeon Lee 2026 (2)¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i? · causal · r2

Omnibus two-way ANOVA on retention test 3 freezing percentage (Fig. 4h) reported a significant CGRP manipulation × Footshock Intensity interaction, F(4,48) = 11,75, ***p < 0.001, with Bonferroni post-hoc group differences at 0.4 and 0.5 mA.

"Two-way ANOVA: signi ficant main effects of CGRP manipulation [ F(1,12) = 21.77, ***p < 0.001], Footshock Intensity [F(4,48) = 37.50, ***p < 0.001], and their interaction [ F(4,48) = 11,75, ***p < 0.001]."

Discussion¶

Related Claims¶

• Cgrp Silencing Expands Avoidance High Intensity
• In the platform-based active avoidance paradigm, 0.3 mA footshock optimally supports cue-evoked active avoidance, with lower intensities yielding weak avoidance and higher intensities promoting freezing that suppresses action — a broader claim this one bears on
• Freezing levels are negatively correlated with active avoidance performance across mice in the platform-based active avoidance paradigm — related
• Low footshock intensities (0.1-0.2 mA) yield weak avoidance learning in both CGRP-silenced and control mice — related