In the platform-based active avoidance paradigm, 0.3 mA footshock optimally supports cue-evoked active avoidance, with lower intensities yielding weak avoidance and higher intensities promoting freezing that suppresses action¶

Claim · All claims
Evidence · 1 study (2 entries) · causal r2 · q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Shock intensity systematically biased freezing over active avoidance, with 0.3 mA optimally supporting active avoidance expression under the present task conditions. → Hanny Hayeon Lee 2026 q3 i? Excluding stay trials confirmed that 0.3 mA performance reflects genuine cue-evoked avoidance rather than passive occupancy of the safe zone. → Hanny Hayeon Lee 2026 (2)

Evidence¶

Hanny Hayeon Lee 2026¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i? · causal · r2

Validation experiment: independent cohorts of mice (n = 6 per group) conditioned at 0.1, 0.2, 0.3, 0.4 or 0.5 mA; CS-only retention tests showed 0.1-0.2 mA groups with persistently low avoidance and 0.4-0.5 mA groups failing, with "0.3 mA providing conditions that optimally supported active avoidance expression".

"behavioural output in the PBA paradigm is strongly shaped by threat intensity, with 0.3 mA providing conditions that optimally supported active avoidance expression underthe present task conditions."

Hanny Hayeon Lee 2026 (2)¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i? · causal · r2

Control analysis of the same validation experiment separated stay trials (conditioning stay rate: 46%; retention test stay rate: 15%) from cue-evoked entries; restricted to cue-evoked platform entries, 0.3 mA mice "were the only group to con- sistently enter the safe zone within the 5 s avoidance success window".

"mice conditioned at 0.3 mA continued to show the strongest cue-evoked avoid- ance performance and, by retention test 3, were the only group to con- sistently enter the safe zone within the 5 s avoidance success window even when analyses were restricted to cue-evoked platform entries"

Discussion¶

Related Claims¶

• Freezing Negatively Correlated Avoidance Pba
• Silencing CGRP neurons in the parabrachial nucleus does not impair active avoidance learning and expands successful avoidance to high footshock intensities — related
• CGRP silencing reduces freezing at high footshock intensities where control mice show significant increases in freezing — a narrower finding that bears on this claim
• Low footshock intensities (0.1-0.2 mA) yield weak avoidance learning in both CGRP-silenced and control mice — related