A positive G×E interaction between the education PGS and SES indicates a favorable SES environment enhances the effect of offspring genome¶

Claim · All claims
Evidence · 1 study · associational r3 · q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? The G×E-interaction model fits significantly better than the main-effects model, with a positive education PGS × SES interdependence. → Guang Guo 2022

Evidence¶

Guang Guo 2022¶

Guang Guo, Meng-Jung Lin and Kathleen Mullan Harris. (2022). Socioeconomic and genomic roots of verbal ability from current evidence. npj Science of Learning 7:22. https://doi.org/10.1038/s41539-022-00137-8

q2 · i? · associational · r3

Table 6 models using a PCA summary score of SES in the combined sample. The likelihood ratio test favors the interaction model, and the article reports the positive interdependence indicates "a favorable SES environment would enhance the effect of offspring genome."

"A likelihood ratio test shows that the G×E-interaction model (−2LogL = 67,058; df = 24) has significantly more explanatory power than the main effects model ( −2LogL = 67,064; df = 22) at the level of 5% with two degrees of freedom. The interdependence between the education PGS and SES is positive"

Discussion¶

Learner Variables¶

• Socioeconomic Status — moderator: an instructional effect differs by group

Related Claims¶

• Children in higher SES families have higher average polygenic scores for educational attainment — related
• Education and cognitive-ability polygenic scores significantly predict verbal ability, with the education PGS far more robust — related
• Incremental R2s for offspring genome, genomic component in parental SES, and environmental SES are about 1.5%, 1.5%, and 7.8%, yielding total genomic R2 of 3% and environmental R2 of 7.8% — related
• Including SES and offspring genome in the same model reduces the education PGS effect by more than 20% and SES effects by about 10–15%, implying 20–30% of parental SES effects are genomic — related
• Parental SES context significantly and simultaneously predicts youth verbal ability in Add Health, with mother's education the largest SES coefficient — related
• School socioeconomic advantage buffers low-polygenic-score students from dropping out of math: the PGS-by-school-SES interaction on persistence is significant and negative — reports the opposite
• School SES and education-PGS each predicted completing Calculus without a significant interaction, and even top-2% polygenic-score students rarely took Calculus — related