Polygenic score predictions are reduced in African American relative to European ancestry samples, significantly so only for educational attainment¶
Claim · All claims
Evidence · 1 study · quant-synthesisr3·q4
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person · recheck by 2027: tool and model accuracy changes quickly
Subclaims¶
Reading the evidence codes
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q4 i? Attainment predictions were 57% and achievement predictions 50% lower in African American than European ancestry samples, but only the attainment difference was statistically significant. → Wilding 2024
Evidence¶
Wilding 2024¶
Wilding, K., Wright, M., & von Stumm, S. (2024). Using DNA to Predict Education: a Meta-analytic Review. Educational Psychology Review. https://doi.org/10.1007/s10648-024-09928-4
q4 · i? · quant-synthesis · r3
Discussion synthesis of the meta-regression results: predictions "were reduced by 57% and 50%, respectively" in African American versus European ancestry samples, with significance only for attainment. The authors attribute this to limited portability of European-GWAS-based scores.
"polygenic score predictions for educational attainment and achievement were reduced by 57% and 50%, respectively, in samples that were described as African American compared to those of European ancestry, although this effect was only significant for educational attainment"
Discussion¶
Related Claims¶
- Only 15% of published polygenic score estimates for education come from non-European ancestry samples, all recruited in the US
- Polygenic scores based on the Lee et al. (2018) GWAS show a meta-analytic association of ρ = 0.27 with educational attainment
- Age at assessment and achievement measure moderate polygenic score predictions of educational achievement; the adjusted pooled estimate rises to ρ = 0.50 — related
- Sample ancestry significantly moderates polygenic score predictions of educational attainment, with stronger predictions in European-ancestry samples — possibly the same claim (merge candidate)
- Polygenic score predictions of education strengthen as GWAS discovery sample sizes increase — related
- Polygenic scores show a meta-analytic association of ρ = 0.24 with educational achievement — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
pgs-predictions-reduced-african-american-samples |
title |
Polygenic score predictions are reduced in African American relative to European ancestry samples, significantly so only for educational attainment |
description |
Polygenic score predictions are reduced in African American relative to European ancestry samples, significantly so only for educational attainment |
status |
review |
evidence_strength |
mixed |
newest_evidence |
2024 |
recheck_by |
2027 |
generated |
by process:wiki-ingest on 2026-10-19 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — wilding-2024 |
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