MoBa genotyped mother-father-child trio sample (N = 40,879)

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Evidence · 7 claims (7 for) · 2 studies (2 causal), q2 · 1 of 2 report an effect size · 7 claims rest on one study

Description

A restricted-access Norwegian Mother, Father and Child Cohort Study dataset containing genotype data for 40,879 mother-father-child trios, administered by the Norwegian Institute of Public Health for research on intergenerational and child-development outcomes.

Components

Claims

• Within-family Mendelian randomization finds little evidence that mothers' or fathers' educational attainment causally affects children's depressive, anxiety, or ADHD traits at age 8 [+M]
• Non-genetic models show small negative associations between parents' years of education and children's depressive traits, which attenuate once confounders are accounted for [+W]
• Children's own polygenic index for educational attainment is negatively associated with their ADHD traits at age 8, independent of parental PGIs [+W]
• In complete-case sensitivity analyses, maternal education showed unexpected positive associations with children's depressive and ADHD-inattention traits [+W]
• Children's own polygenic index for educational attainment is negatively associated with their depressive traits at age 8 [+W]
• Two-sample MR finds inverse-variance weighted estimates linking maternal education to fewer depressive but more ADHD-inattention traits, with other estimators consistent with the null [+W]
• Within-family cogPGS effect on crystallized intelligence was roughly half the between-family effect, indicating passive genotype-environment correlation [+W]

Related Products and Programmes

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Key Sources

• Hughes, A. M., Torvik, F. A., van Bergen, E., Hannigan, L. J., Corfield, E. C., Andreassen, O. A., Ystrom, E., Ask, H., Davey Smith, G., Davies, N. M. & Havdahl, A. (2024). Parental education and children’s depression, anxiety, and ADHD traits, a within-family study in MoBa. npj Science of Learning. https://doi.org/10.1038/s41539-024-00260-8

Page metadata

Field	Value
type	product
id	moba-genotyped-mother-father-child-trio-sample-n-40879
title	MoBa genotyped mother-father-child trio sample (N = 40,879)
description	A restricted-access Norwegian Mother, Father and Child Cohort Study dataset containing genotype data for 40,879 mother-father-child trios, administered by the Norwegian Institute of Public Health for research on intergenerational and child-development outcomes.
status	review
product_kind	dataset
generated	by process:settle-candidates on 2026-10-26
trust	unverified — no one has confirmed this page's content

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